Publications
Bacteria exploit viral dormancy to establish CRISPR-Cas immunity
Keith NC, Snyder RA, Euler CA, Modell JW. Cell Host & Microbe. In press. 2025.
A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage
Stoltzfus MJ, Workman RE, Keith NC, Modell JW. Nature Microbiology. 2024 July 12.
doi:10.1038/s41564-024-01748-0
Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense
Workman RE, Stoltzfus MJ, Keith NC, Euler CW, Bondy-Denomy J, Modell JW. Cell Reports. 2024 Feb 29.
doi:10.1016/j.celrep.2024.113849
Originally in bioRxiv
Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations
Hossain AA, McGinn J, Meeske AJ, Modell JW*, Marraffini LA*. Cell Host & Microbe. 2021 Sept 27. doi:10.1016/j.chom.2021.09.001
*Co-corresponding authors
A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression
Workman RE, Pammi T, Nguyen BTK, Graeff LW, Smith E, Sebald SM, Stoltzfus MJ, Euler CW, Modell JW. Cell. 2021 Jan 8. doi:10.1016/j.cell.2020.12.017
CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity
Modell JW, Jiang W, Marraffini LA. Nature. 2017 Apr 6.
doi:10.1038/nature21719
Cas9 specifies functional viral targets during CRISPR–Cas adaptation
Heler R, Samai P, Modell JW, Weiner C, Goldberg GW, Bikard D, Marraffini LA. Nature. 2015 Mar 12. doi:10.1038/nature14245pbio.1001977