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A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage

Stoltzfus MJ, Workman RE, Keith NC, Modell JW. Nature Microbiology. In press. 

Originally in bioRxiv

Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense

Workman RE, Stoltzfus MJ, Keith NC, Euler CW, Bondy-Denomy J, Modell JW. Cell Reports. 2024 Feb 29.


Originally in bioRxiv

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Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations

Hossain AA, McGinn J, Meeske AJ, Modell JW*, Marraffini LA*. Cell Host & Microbe. 2021 Sept 27. doi:10.1016/j.chom.2021.09.001

*Co-corresponding authors

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A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Workman RE, Pammi T, Nguyen BTK, Graeff LW, Smith E, Sebald SM, Stoltzfus MJ, Euler CW, Modell JW. Cell. 2021 Jan 8. doi:10.1016/j.cell.2020.12.017

Originally in bioRxiv

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CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity

Modell JW, Jiang W, Marraffini LA. Nature. 2017 Apr 6.


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Cas9 specifies functional viral targets during CRISPR–Cas adaptation

Heler R, Samai P, Modell JW, Weiner C, Goldberg GW, Bikard D, Marraffini LA. Nature. 2015 Mar 12. doi:10.1038/nature14245pbio.1001977

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